Manufacturer: Cipla, India
Pharmaceutical name: Lamivudine, Nevirapine, Stavudine
Pack: 30 pills (150 mg / 200 mg / 30 mg)
Triomune is a combination therapy designed for individuals infected with Human Immunodeficiency Virus (HIV). It comprises three distinct antiretroviral medications - Lamivudine (150mg), Nevirapine (200mg), and Stavudine (30mg).
Triomune is available in a package containing 30 tablets. Each tablet includes 30mg of Stavudine, 150mg of Lamivudine, and 200mg of Nevirapine, which corresponds to half the usual daily dose for each component. It is advised to take one tablet twice a day with a glass of water as long as directed by your physician.
The use of antiretroviral medications like those in Triomune can sometimes lead to severe cases of lactic acidosis, which can be fatal. Symptoms that may indicate the onset of lactic acidosis include nausea, vomiting, abdominal discomfort, difficulty breathing, lack of appetite, weight loss, or muscle weakness. Inform your doctor if you experience any of these side effects while using Triomune.
Other side effects associated with the individual ingredients include:
Stavudine: serious peripheral neuropathy (often dose-related and more prevalent in individuals with advanced HIV infection or those who have had previous experiences of peripheral neuropathy).
Lamivudine: nausea, vomiting, headaches, abdominal pain and discomfort, peripheral neuropathy, joint pain, muscle pain, skin rashes, pancreatitis.
Nevirapine: possible development of rash and liver toxicity (these effects can be potentially life-threatening and should be closely monitored).
Do not use Triomune if you have ever had an allergic reaction to any of its active ingredients (Stavudine, Lamivudine, and Nevirapine). Triomune is contraindicated during pregnancy or while breastfeeding. Avoid taking Triomune if you have kidney or liver disorders.
Triomune should only be used if you have previously undergone treatment for HIV, specifically with nevirapine.
Certain medications may interact adversely with Triomune, potentially causing it to be ineffective or negatively affecting the other drugs.